Two-Drug Combinations as First-Step Antihypertensive Treatment
نویسندگان
چکیده
منابع مشابه
Diuretic Versus -Blocker as First-Step Antihypertensive Therapy
The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) was a randomized, double-blind, active, controlled clinical trial conducted to determine whether newer antihypertensive agents, including doxazosin, an -blocker, differ from chlorthalidone, a diuretic, with respect to coronary heart disease (CHD) and other cardiovascular disease (CVD) events in hypertensive...
متن کاملTrends in antihypertensive drug treatment.
To the Editor: It is disappointing to read once again that “b-blockers and thiazide diuretics are the only antihypertensive agents that have been shown to reduce cardiovascular mortality.”1 In these days of evidence-based medicine, we must ask: where is the evidence for this statement? The basic data referenced by Wang et al1 are those of the meta-analysis of Psaty et al,2 which are also shown ...
متن کاملIndividualization of Antihypertensive Drug Treatment
Antihypertensive drug classes are usually classified as 1st, 2nd, 3rd, and 4th or 5th choice to help physicians select the drug most suitable for treatment initiation among the very many classes available to lower blood pressure (BP) in patients with a BP elevation. However, this approach was appropriate decades ago when several drugs had inconveniences that made their use in monotherapy inadvi...
متن کاملSafety of Fixed Dose of Antihypertensive Drug Combinations Compared to (Single Pill) Free-Combinations
To compare serious adverse events of fixed-dose dual antihypertensive drug combination (FIXED) to component-based free-combination (FREE).A population-based nationwide cohort from the French Health Insurance System included subjects over 50 years with first time claims (new user) in the second half of 2009 for a calcium-channel blocker or a thiazide-like diuretic in combination with either an a...
متن کاملFixed Combinations in Antihypertensive Therapy
Several studies have now confirmed that optimal targets of blood pressure (BP) could rarely be reached by monotherapy and various drug combinations are required to do this more effectively. However, the best way to increase patient compliance may be fixed combinations of two or more drugs in a single pill. With further research into mechanisms of action and development of new drugs, it became e...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2019
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.118.313294